Singh, Tanya; Adekoya, Olayiwola; Jayaram, B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-14)
Matrix metalloproteinases (MMPs) consist of a class of proteins required for normal tissue function. Their
over expression is associated with many disease states and hence the interest in MMPs as drug targets.
Almost all MMP inhibitors have been reported to fail in clinical trials due to lack of specificity. Zinc in the
binding site of metalloproteinases performs essential biological functions ...